Puerto Natales has an airport, so different airlines offer tickets from Santiago or Puerto Montt in the summer season, so flying direct is possible. If you arrive in Punta Arenas you can get to Puerto Natales via car. You will take Route 9 North, the main road that takes you from Punta Arenas to Puerto Natales. This is a 247 km drive. The other gateway is from Argentina through the border crossing at Paso Don Guillermo, Casas Viajas and Dorotea.